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Walter Swardfager*

Email: w.swardfager@utoronto.ca
Sunnybrook Health Sciences Centre
Collaborative Program in Neuroscience (CPIN) member

Research interests: Dr. Swardfager’s research focuses on symptoms of depression and cognitive decline, particularly in later life. On-going studies explore the neuroimmunological intersection between psychiatric and metabolic diseases as an avenue to discover biomarkers, elucidate vulnerability factors and implicate new treatments. The mechanisms by which cardiopulmonary fitness and exercise interventions counteract neurodegenerative processes are of particular interest. Disease areas of focus include depressive disorders, Type 2 diabetes, Alzheimer’s disease and stroke, which often occur together with disastrous consequences. Techniques used include genomics, neuroimaging, serum biomarkers, and neuropsychiatric assessments. The lab also uses public health records to examine the impact of comorbid conditions (e.g. depression and diabetes) on long-term health outcomes in those with chronic diseases.Current studies include: • improving effectiveness of exercise interventions for people with Type 2 diabetes • understanding genetic vulnerability to cerebral white matter disease in normal aging and neurodegenerative disorders •using metabolic changes in depressive episodes as biomarkers to implicate new avenues for treatment • mitigating the impact of diabetes and depression on functional and cognitive recovery from stroke

Assistant Professor
Department of Pharmacology & Toxicology - SGS Appointment

Sunnybrook Hospital Profile 

Pubmed search of Walter Swardfager's publications